Which adverse effect is commonly reported with bupropion?

Which adverse effect is commonly reported with bupropion?

• A. Insomnia
• B. Weight gain
• C. Hypotension
• D. Dry mouth

Answer: (A)

Insomnia comes from the activating effects of bupropion. It inhibits norepinephrine and dopamine reuptake, which boosts alertness and energy in the brain. That stimulation can make it hard to fall asleep or stay asleep, especially if the dose is taken later in the day. Because of this, clinicians often recommend taking it in the morning to lessen sleep disturbance. Other listed effects can occur but are less characteristic: weight change with bupropion tends toward weight loss rather than gain, dry mouth can happen but is not as consistently reported, and hypotension is not a typical feature.

Insomnia comes from the activating effects of bupropion. It inhibits norepinephrine and dopamine reuptake, which boosts alertness and energy in the brain. That stimulation can make it hard to fall asleep or stay asleep, especially if the dose is taken later in the day. Because of this, clinicians often recommend taking it in the morning to lessen sleep disturbance. Other listed effects can occur but are less characteristic: weight change with bupropion tends toward weight loss rather than gain, dry mouth can happen but is not as consistently reported, and hypotension is not a typical feature.