Which adverse effect is associated with bupropion, particularly at higher doses?

Which adverse effect is associated with bupropion, particularly at higher doses?

• A. Weight gain
• B. Seizure
• C. Hypotension
• D. Rash

Answer: (B)

Bupropion has a dose-related risk of lowering the brain’s seizure threshold, so seizures become more likely as the dose increases or in people with predisposing factors. This risk is amplified in those with a history of seizures, eating disorders (like bulimia or anorexia), electrolyte disturbances, or when alcohol or certain sedatives are abruptly withdrawn. Because of this, seizures are the most notable adverse effect at higher doses. While other effects such as changes in weight, blood pressure, or skin reactions can occur, they don’t rise as specifically or predictably with higher dosing as the seizure risk does.

Bupropion has a dose-related risk of lowering the brain’s seizure threshold, so seizures become more likely as the dose increases or in people with predisposing factors. This risk is amplified in those with a history of seizures, eating disorders (like bulimia or anorexia), electrolyte disturbances, or when alcohol or certain sedatives are abruptly withdrawn. Because of this, seizures are the most notable adverse effect at higher doses. While other effects such as changes in weight, blood pressure, or skin reactions can occur, they don’t rise as specifically or predictably with higher dosing as the seizure risk does.